Rituximab-Related Pulmonary Toxicity
作者： Yair Herishanu , Chava Perry , Aaron Polliack
DOI: 10.1007/978-3-642-15742-4_64
关键词: Rituximab 、 Pulmonary toxicity 、 Crackles 、 Lung 、 Vincristine 、 Prednisone 、 Pathology 、 Medicine 、 CHOP 、 Diffuse alveolar damage
摘要: We report the case of an 80-year-old man treated for follicular grade 3B non-Hodgkin’s lymphoma (NHL). Immunochemotherapy consisted rituximab (375 mg/m2) and CHOP (cyclophosphamide, doxorubicin, vincristine prednisone) every 21 days. Since patient complained mild dyspnea on effort with bilateral basilar crackles audible auscultation, PET-CT was performed showed disappearance initial 18F-FDG uptake, but new abnormal sites uptake were evident in sub-pleural areas lung, mostly right side. After starting fifth cycle rituximab-CHOP, worsened. Chest-X ray HRCT consistent interstitial infiltration, including air-space consolidation, “ground-glass” opacities, small pulmonary cysts thickening interlobular septa also seen. Trans-bronchial biopsy revealed inflammation lung parenchyma, as well swelling hyperplasia atypical type II alveolar cells. Alternative diagnoses than drug-related toxicity are discussed, a literature review is provided.
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sci-hub.st 参考文章(59)
Neutropenia in patients treated with rituximab. The New England Journal of Medicine. ,vol. 348, pp. 2691- 2694 ,(2003) , 10.1056/NEJM200306263482620
Nicole Selenko, Otto Majdic, Ulrich Jäger, Christian Sillaber, Johannes Stöckl, Walter Knapp, None, Cross-priming of cytotoxic T cells promoted by apoptosis-inducing tumor cell reactive antibodies? Journal of Clinical Immunology. ,vol. 22, pp. 124- 130 ,(2002) , 10.1023/A:1015463811683
R. A. Matthay, D. A. White, J. A. D. Cooper, Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs. The American review of respiratory disease. ,vol. 133, pp. 488- 505 ,(1986) , 10.1164/ARRD.1986.133.2.321
Interstitial pneumonitis related to rituximab therapy. The New England Journal of Medicine. ,vol. 348, pp. 2690- ,(2003) , 10.1056/NEJM200306263482619
Dasja Pajkrt, Annemieke Manten, Tom van der Poll, Monique M.C. Tiel-van Buul, Jaap Jansen, Jan Wouter ten Cate, Sander J.H. van Deventer, Modulation of Cytokine Release and Neutrophil Function by Granulocyte Colony-Stimulating Factor During Endotoxemia in Humans Blood. ,vol. 90, pp. 1415- 1424 ,(1997) , 10.1182/BLOOD.V90.4.1415
U. Winkler, M. Jensen, O. Manzke, H. Schulz, V. Diehl, A. Engert, Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal Antibody (Rituximab, IDEC-C2B8) Blood. ,vol. 94, pp. 2217- 2224 ,(1999) , 10.1182/BLOOD.V94.7.2217.419K02_2217_2224
John C. Byrd, Jamie K. Waselenko, Thomas J. Maneatis, Timothy Murphy, Frank T. Ward, Brian P. Monahan, Melissa A. Sipe, Sarah Donegan, Christine A. White, Rituximab Therapy in Hematologic Malignancy Patients With Circulating Blood Tumor Cells: Association With Increased Infusion-Related Side Effects and Rapid Blood Tumor Clearance Journal of Clinical Oncology. ,vol. 17, pp. 791- 795 ,(1999) , 10.1200/JCO.1999.17.3.791
Junji Hiraga, Yasuhiro Kondoh, Hiroyuki Taniguchi, Tomohiro Kinoshita, Tomoki Naoe, A case of interstitial pneumonia induced by rituximab therapy. International Journal of Hematology. ,vol. 81, pp. 169- 170 ,(2005) , 10.1532/IJH97.04163
Bungo Saito, Tsuyoshi Nakamaki, Daisuke Adachi, Junko Suzuki, Shigeru Tomoyasu, Acute Respiratory Distress Syndrome during the Third Infusion of Rituximab in a Patient with Follicular Lymphoma International Journal of Hematology. ,vol. 80, pp. 164- 167 ,(2004) , 10.1532/IJH97.04047
R. Swords, D. Power, M. Fay, R. O'Donnell, P.T. Murphy, Interstitial pneumonitis following rituximab therapy for immune thrombocytopenic purpura (ITP). American Journal of Hematology. ,vol. 77, pp. 103- 104 ,(2004) , 10.1002/AJH.20135