Retention of inhaled particles in hamsters with pulmonary fibrosis.
作者： T. D. Sweeney , J. D. Brain , A. F. Tryka , J. J. Godleski
DOI: 10.1164/ARRD.1983.128.1.138
关键词: Lung volumes 、 Geometric standard deviation 、 Respiratory system 、 Pathology 、 Fibrosis 、 Pulmonary fibrosis 、 Interstitial pulmonary fibrosis 、 Animal science 、 Evenness index 、 Bleomycin 、 Chemistry
摘要: Aerosol retention was studied in hamsters 30, 60, and 90 days after the initiation of interstitial pulmonary fibrosis by a combination bleomycin (bleo), 0.16 U/100 g body weight given intratracheally, 02, 70% for 72 h. Groups bleo-02-treated control animals were exposed (awake) 25 min to 99mTc-labeled insoluble aerosol (activity median aerodynamic diameter, 0.45μm; geometric standard deviation, 1.3). Within 5 exposure, killed their lungs excised dried at total lung capacity, sliced into 1-mm sections. Slices dissected pieces, an evenness index (El) calculated each piece . With uniformity retention, all Els would be 1. The distribution had mean 1.0 SD 0.27; 0% ⩽0.20. Total diminished less uniform animals. At 30 days, increased 0.62, 6% 60 nonuniformity decreased but stil...
sci-hub.se 参考文章(25)
Bates Dv, Hatch Tf, Mercer Tt, Fish Br, Morrow Pe, Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics. Health Physics. ,vol. 12, pp. 173- 207 ,(1966)
Godleski Jj, Skornik Wa, Brain Jd, Tryka Af, Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Morphologic assessment. The American review of respiratory disease. ,vol. 126, pp. 1074- ,(1982) , 10.1164/ARRD.1982.126.6.1074
Peter A. Valberg, Joseph D. Brain, Deposition of Aerosol in the Respiratory Tract1–3 The American review of respiratory disease. ,vol. 120, pp. 1325- ,(2015) , 10.1164/ARRD.1979.120.6.1325
Ronald G. Crystal, Allan J. Hance, The connective tissue of lung. The American review of respiratory disease. ,vol. 112, pp. 657- 711 ,(1975) , 10.1164/ARRD.1975.112.5.657
Jere Mead, TAMOTSU Takishima, DAVID Leith, None, Stress distribution in lungs: a model of pulmonary elasticity. Journal of Applied Physiology. ,vol. 28, pp. 596- 608 ,(1970) , 10.1152/JAPPL.1970.28.5.596
J D Brain, The respiratory tract and the environment. Environmental Health Perspectives. ,vol. 20, pp. 113- 126 ,(1977) , 10.1289/EHP.7720113
Joseph D. Brain, Dwyn E. Knudson, Sergei P. Sorokin, Michael A. Davis, Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environmental Research. ,vol. 11, pp. 13- 33 ,(1976) , 10.1016/0013-9351(76)90107-9
J. Milic-Emili, Radioactive xenon in the evaluation of regional lung function Seminars in Nuclear Medicine. ,vol. 1, pp. 246- 262 ,(1971) , 10.1016/S0001-2998(71)81021-8
Steven L. Sneddon, Joseph D. Brain, Persistent apex to base gradients of aerosol deposition in rats Respiration Physiology. ,vol. 46, pp. 113- 124 ,(1981) , 10.1016/0034-5687(81)90094-3
MARVIN I. TILLERY, A concentric aerosol spectrometer. American Industrial Hygiene Association Journal. ,vol. 35, pp. 62- 74 ,(1974) , 10.1080/0002889748507007