Animal Models to Study for Pollutant Effects

摘要: Publisher Summary This chapter emphasizes the use of animal models that can be rendered more susceptible to air pollution health effects. Much understanding toxicity major pollutants, such as tropospheric ozone, sulfur dioxide, nitrogen particulate matter, carbon monoxide, and other “air toxic” pollutants (for example, phosgene metal/acid aerosols) has been derived from studies using laboratory models. Although a variety inbred or outbred strains mice, rats, hamsters, guinea pigs, rabbits, dogs, primates have used in inhalation toxicology studies, most employed healthy animals examine basic mechanisms underlying pollutant-induced injury. It recognized human susceptibilities effects vary dramatically depending on pre-existent conditions host, diseases, nutritional deficiencies. Pulmonary structure pattern flow widely between human, therefore, it is critical model chosen wisely. Selection appropriate depends upon condition being modeled how closely mimics terms its biological handling pollutant.