Rodent models of susceptibility: what is their place in inhalation toxicology?

摘要: There is renewed interest in inhalation toxicology regarding 'susceptibility' as associated with host variables, including genetics, age, diet, and disease. This derives from epidemiology that shows air pollution-related human mortality/morbidity, especially among individuals cardiopulmonary Several animal models experimental or genetically-based diseases are now being incorporated into studies to investigate mechanisms underlie susceptibility. However, current have strengths limitations how they mimic the essential features of diseases. To date, pulmonary hypertension, bronchitis, asthma, cardiovascular disease, but not emphysema, appear exhibit greater susceptibility pollution particulate matter. As humans, appears involve multiple genetic environmental factors, poorly understood, database information growing rapidly. existing gain wider use, our understanding will improve encourage refinements/development integrate both factors better condition.