No circulating human cytomegalovirus in 14 cases of glioblastoma.

摘要: Cobbs et al have reported that many gliomas contain human cytomegalovirus (HCMV) gene products.1 Mitchell 80% of patients with diagnosed glioblastoma multiforme HCMV DNA in their peripheral blood; seropositive normal donors and other surgical did not.2 However, Baumgarten infection tumor cells the nervous system is not detectable standardized pathologico-virological diagnostics,3 calling into question etiologic role glioblastoma.4 In our own studies, we collected blood anticoagulated tubes from 14 newly who were referred for radiation therapy.5 We used standard methods detecting by reverse transcriptase PCR6 culture.7 None had circulating detected. blood.2 The chance a single patient having would be 20% or 0.2. Therefore, none 0.214 P = 1.6 × 10−10. Moreover, seropositivity data incidence do support HCMV-glioblastoma association since seroprevalence rates are consistently related to rates.8 is, however, socioeconomic status. significantly lower whites than blacks Hispanics (Mexican Americans), while higher Hispanics. But women men, although more common men. possible cannot readily substantiated rates. Age at may involved both status, as described above. early childhood, which groups, protective against glioblastoma, whereas later childhood adulthood risk factor glioblastoma. If so, similar paralytic polio, low poor hygiene, protective.9