Human cytomegalovirus infection in tumor cells of the nervous system is not detectable with standardized pathologico-virological diagnostics

摘要: Human cytomegalovirus (HCMV), a member of the herpes virus family, persists after primary (normally unrecognized) infection for remainder patient's life. The seroprevalence ranges from ∼50% to 100% within population, and higher prevalence levels are detected in females than males. Lower socioeconomic status is associated with increased HCMV seroprevalence,1,2 also major pathogen immunocompromised individuals. Although reactivates varying frequency results detectable blood shedding, disease an extremely rare event immunocompetent individuals.3 During critical illness patients, reactivation may be prolonged hospitalization death.4 For decades, it has been speculated that play role course various cancer diseases.5,6 Experimental evidence suggested cause oncomodulatory activity (ie, modulate malignant properties) established (or other tumor-associated) cells enhance malignancy even though not tumor proven transformational potential.5,7 In 2002, idea HCMV-induced oncomodulation was strongly supported by clinical study reported on detection proteins oligonucleotides very high percentage gliomas.8 This followed further studies reporting tissues different entities, including colorectal cancer, prostate medulloblastoma, neuroblastoma.9–13 However, groups have skeptical found fractions tumors.14–19 Interestingly, correlating serostatus missing. To fill this gap, we present here systematic immunohistochemistry quantitative (q)PCR patients nervous system tumors, subgroup glioblastoma which performed combined analysis data immunohistochemical tissues.