METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.

摘要: The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that METTTL13 protein is aberrant expression variety human cancers METTL13 was involved oncogenic pathways. However, role been unexplored to date. Here, lower tissue samples cell lines than normal lines. downregulated late stages disease maintained at low level throughout tumor progression process based on node metastasis (TNM) staging. Further research suggested negatively regulates proliferation reinstates G1/S checkpoint via coordinated downregulation CDK6, CDK4 CCND1, decreased phosphorylation Rb subsequent delayed cycle progression. Moreover, METTL13-dependent inhibition migration invasion mediated by FAK (Focal adhesion kinase) phosphorylation, AKT (v-akt murine thymoma viral oncogene) β-catenin MMP-9 expression. These integrated efforts have identified as a suppressor might provide promising approaches prevention.