ADP-dependent platelet function prior to and in the early course of pediatric liver transplantation and persisting thrombocytopenia are positively correlated with ischemia/reperfusion injury

摘要: Little is known about the role of platelets in relation to ischemia/reperfusion injury (IRI) liver graft especially children. Thrombocyte function was prospectively analysed 21 consecutive pediatric transplantation (pLT) patients by platelet aggregometry secondary adenosine diphosphate (ADP), collagen, and von Willebrand factor activator ristocetin (VWF:rco). Post-OP serum levels ALT were used divide into groups with high (highHD, n = 8) low (lowHD, 13) hepatocellular damage. Clinically, highHD-patients showed impaired plasmatic coagulation elevated bilirubin early after pLT when compared lowHD-patients. Further, counts markedly decreased between pre-OP postreperfusion (postrep.) highHD group (P 0.003) did not recuperate POD6. In lowHD individuals thrombocytopenia improved from both < 0.05) postrep. 0.001) respectively towards Experimental thrombocyte testing revealed that before reperfusion only ADP-dependent aggregation correlated injury, function. During first 48 h reperfusion, all inducers tested demonstrated group. Our data suggest a possible their aggregative status IRI subsequent clinical pLT. Reperfusion-independent ADP-triggered may be determinant for hepatic recipient.