Hydrogen exchange rate of tyrosine hydroxyl groups in proteins as studied by the deuterium isotope effect on Cζ chemical shifts

作者: Mitsuhiro Takeda , JunGoo Jee , Akira Mei Ono , Tsutomu Terauchi , Masatsune Kainosho

DOI: 10.1021/JA907911Y

关键词: ChemistryAnalytical chemistryDeuteriumKinetic isotope effectInorganic chemistryTyrosineHydrogen exchangeChemical shift

摘要: We describe a new NMR method for monitoring the individual hydrogen exchange rates of hydroxyl groups tyrosine (Tyr) residues in proteins. The utilizes (2S,3R)-[β2,e1,2-2H3;0,α,β,ζ-13...

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