Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

摘要: The p53 protein is the most studied tumor suppressor and pathway has been shown to mediate cellular stress responses that are disrupted when cancer develops. After DNA damage, activated as transcription factor directly induce expression of target genes involved in cell-cycle arrest, repair, senescence and, importantly, apoptosis. Post-translational modifications essential for activation selection genes. homeodomain-interacting kinase-2 (HIPK2) a crucial regulator apoptotic function by phosphorylating its N-terminal serine 46 (Ser46) facilitating Lys382 acetylation at C-terminus. HIPK2 numerous genotoxic agents can be deregulated tumors several conditions including hypoxia. Recent findings suggest active/inactive affect multiple unexpected ways. This makes well interesting targets therapy. Hence, understanding role activator may provide important insights process progression, also serve point diagnostic therapeutical aspects cancer.