HIPK2 modification code for cell death and survival

摘要: Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine that participates in the regulation of diverse cellular activities as transcriptional cofactor and signal transducer. HIPK2 senses various signaling cues turn phosphorylate downstream substrates to coordinate developmental processes, cell cycle regulation, proliferation, differentiation, DNA damage response. functions are affected by its catalytic activity, stability, subcellular localization, which dynamically regulated post-translational modifications such polyubiquitination, SUMOylation, phosphorylation, acetylation. not modified with small molecules and/or peptides individually or independently, but combinatorial manner referred “HIPK2 modification code.” integrates different doses ROS stimuli, reflected unique patterns modification. Hence, ...