Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission

摘要: Some noradrenergic noncholinergic (NANC) autonomic and enteric nerves utilize NO or an NO-like factor as a transmitter have been termed nitrergic. They contain characteristic neuronal isozyme of synthase (NOS). Synthesis from L-arginine requires number cofactors, which haem terahydrobiopterin are the most recently recognized. The entry Ca2+ produced by stimulation nitrergic activates NOS results in release transmitter. It acts on soluble guanylate cyclase effector smooth muscle cells, resulting rise cyclic GMP level hence relaxation. Nitrergic neuroeffector junctions gastrointestinal tract may also include interstitial cells. Cotransmitters, such ATP VIP, be released with Further work is required to determine its functional interactions other transmitters, modulation synthesis release, identification exact nature