Drug resistance mechanism of PncA inMycobacterium tuberculosis
作者： Vidya Rajendran , Rao Sethumadhavan
DOI: 10.1080/07391102.2012.759885
关键词: Microbiology 、 Pyrazinamide 、 Pyrazinoic acid 、 Docking (molecular) 、 Tuberculosis 、 PncA 、 Biology 、 Drug resistance 、 Mutant 、 Mycobacterium tuberculosis 、 Molecular biology 、 Structural biology 、 General Medicine
摘要: Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant PZA represents public problem, as both first- and second-line treatment regimens include PZA. It becomes toxic Mycobacterium when converted pyrazinoic acid by the bacterial pyrazinamidase (PncA) enzyme. Resistance caused mainly loss enzyme activity mutation, mechanism resistance not completely understood. In our studies, we analysed three mutations (D8G, S104R C138Y) PncA which are involved towards Binding pocket analysis solvent accessibility analysis, molecular docking interaction were performed understand behaviour mutant enzymes with Molecular dynamics simulations conducted three-dimensional (3D) conformational native mutants PncA. Our analy...
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