Ribosomal protein production in normal and anucleolate Xenopus embryos: regulation at the posttranscriptional and translational levels
作者： P PIERANDREIAMALDI , E BECCARI , I BOZZONI , F AMALDI
DOI: 10.1016/S0092-8674(85)80127-6
关键词: Xenopus 、 Polysome 、 Ribosomal RNA 、 Gene expression 、 Ribosomal protein 、 Cell biology 、 Messenger RNA 、 Biology 、 Molecular biology 、 Nucleolus 、 Mutant
摘要: We have studied the regulation of ribosomal protein (r-protein) synthesis in Xenopus anucleolate mutants, which lack genes for rRNA. The accumulation mRNA two r-proteins analyzed parallels controls up to stage 30. This is mobilized onto polysomes and translated as normal embryos, but are unstable absence rRNA assemble with. A translational control rp-mRNA distribution between mRNPs observed, this not due an autogenous by r-proteins. After 30 amount declines specifically mutants because transcripts unstable. Considering temporal correlation event onset r-protein we suggest that operates at level transcript stability.
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