Operation in patients with incurable colon cancer—Is it worthwhile?

摘要: PURPOSE: This study was designed to identify objective criteria that might help surgeons decide which patients with incurable colon cancer will benefit from palliative surgery and not. METHODS: Charts of 68 were reviewed. Fifty-seven underwent resection, six had a bypass nonresectable cancer, five no at all. Time death the major end point study. Minor points postoperative morbidity mortality. Independent variables analyzed comorbidity, preoperative carcinoembryonic antigen, liver function tests, extent metastases, stage site tumor, tumor cell differentiation. RESULTS: There deaths, complications. Mean survival after resection 10.6 months, 3.4 diagnosis in not operated on 2 months. Patients >50 percent their replaced by significantly worse than those <50 involvement (mean, 4.2 ± 4 standard deviation (SD)vs.14.4 SD;P< 0.003, Wilcoxon's rank-sum test). Tumor differentiation also influenced (poor, mean 8.4 8.2 SD; well/moderate, 12.5 ±9.2 0.02). No other variable significant effect survival. CONCLUSION: Resection primary disease has relatively high mortality but is worthwhile as long hepatic metastases occupy less 50 volume.