N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress.

摘要: Reactive oxygen species (ROS) and proinflammatory cytokines produced by immune cells cause the oxidative stress involved in septic shock induced endotoxin. This can be controlled to a certain degree antioxidants, which is specially important for type of cell, i.e. phagocyte, that uses ROS kill microorganisms needs antioxidants order support its functions. In previous study we have observed changes several functions peritoneal macrophages from BALB/c mice with lethal endotoxic caused intraperitoneal injection Escherichia coli lipopolysaccharide (LPS) (100 u mg/kg), were associated high production superoxide anion. N -acetylcysteine (NAC) thiolic antioxidant improves response, when administered intraperitoneally (150 mg/kg) at 30 min after LPS it counteracts effects on lymphocytes. present work, studied ...