Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain.

作者： Min Shi , Margaretha G.M. Roemer , Bjoern Chapuy , Xiaoyun Liao , Heather Sun

关键词: Phenotype 、 Immunohistochemistry 、 Cell 、 Biology 、 Lymphoma 、 Pathology 、 Mediastinal (Thymic) Large B-Cell Lymphoma 、 Programmed cell death 1 ligand 2 、 Gene dosage 、 Gene duplication

摘要: Primary mediastinal (thymic) large B-cell lymphoma (PMBL) and diffuse (DLBCL) are tumors with distinct clinical molecular characteristics that difficult to distinguish by histopathologic phenotypic analyses alone. Programmed cell death 1 ligand 2 (PD-L2) is a s

参考文章(36)

Christiane Copie-Bergman, Philippe Gaulard, Leı̈la Maouche-Chrétien, Josette Brière, Corinne Haioun, Miguel A. Alonso, Paul-Henri Roméo, Karen Leroy, The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood. ,vol. 94, pp. 3567- 3575 ,(1999) , 10.1182/BLOOD.V94.10.3567.422K06_3567_3575

S Joos, MI Otano-Joos, S Ziegler, S Bruderlein, S du Manoir, M Bentz, P Moller, P Lichter, Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene Blood. ,vol. 87, pp. 1571- 1578 ,(1996) , 10.1182/BLOOD.V87.4.1571.BLOODJOURNAL8741571

Martin Bentz, Thomas F. E. Barth, Silke Br�derlein, Daliah Bock, Michael J. Schwerer, Michael Baudis, Stefan Joos, Andreas Viardot, Alfred C. Feller, Hans-Konrad M�ller-Hermelink, Peter Lichter, Hartmut D�hner, Peter M�ller, Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line. Genes, Chromosomes and Cancer. ,vol. 30, pp. 393- 401 ,(2001) , 10.1002/1098-2264(2001)9999:9999<::AID-GCC1105>3.0.CO;2-I

Weiping Zou, Immunosuppressive networks in the tumour environment and their therapeutic relevance Nature Reviews Cancer. ,vol. 5, pp. 263- 274 ,(2005) , 10.1038/NRC1586

Michael R. Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd R. Golub, Jeffery L. Kutok, Margaret A. Shipp, Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma Blood. ,vol. 116, pp. 3268- 3277 ,(2010) , 10.1182/BLOOD-2010-05-282780

Peter Möller, Marco Paulli, Jörn Sträter, Umberto Gianelli, Marie-Thérèse Rousset, Marcello Gambacorta, Ester Orlandi, Catherine Klersy, Thierry Lavabre-Bertrand, Enrica Morra, Christian Manegold, Mario Lazzarino, Umberto Magrini, Mediastinal B-cell lymphoma: a study of its histomorphologic spectrum based on 109 cases. Human Pathology. ,vol. 30, pp. 178- 187 ,(1999) , 10.1016/S0046-8177(99)90273-3

D. Cazals-Hatem, E. Lepage, P. Brice, A. Ferrant, M. F. d'Agay, E. Baumelou, J. Brière, M. Blanc, P. Gaulard, P. Biron, D. Schlaifer, J. Diebold, J. Audouin, Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA ("Groupe d'Etude des Lymphomes de l'Adulte") study. The American Journal of Surgical Pathology. ,vol. 20, pp. 877- 888 ,(1996) , 10.1097/00000478-199607000-00012

Peter W.M. Johnson, Andrew J. Davies, Primary Mediastinal B-Cell Lymphoma Hematology. ,vol. 2008, pp. 349- 358 ,(2008) , 10.1182/ASHEDUCATION-2008.1.349

Kieron Dunleavy, Stefania Pittaluga, Lauren S. Maeda, Ranjana Advani, Clara C. Chen, Julie Hessler, Seth M. Steinberg, Cliona Grant, George Wright, Gaurav Varma, Louis M. Staudt, Elaine S. Jaffe, Wyndham H. Wilson, Dose-Adjusted EPOCH-Rituximab Therapy in Primary Mediastinal B-Cell Lymphoma The New England Journal of Medicine. ,vol. 368, pp. 1408- 1416 ,(2013) , 10.1056/NEJMOA1214561

10.

Yansheng Hao, Bjoern Chapuy, Stefano Monti, Heather H. Sun, Scott J. Rodig, Margaret A. Shipp, Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth In Vitro and In Vivo Clinical Cancer Research. ,vol. 20, pp. 2674- 2683 ,(2014) , 10.1158/1078-0432.CCR-13-3007

Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain.

来源期刊

我的账户

Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain.

来源期刊

相似文章 10

我的账户