Efficacy and safety of DALI LDL-apheresis at high blood flow rates: a prospective multicenter study.

摘要: Direct adsorption of lipids (DALI) is the first LDL-apheresis method compatible with whole blood. Usually, blood flow rate adjusted at 60–80 ml/min, which results in session times about 2 hr. The present study was performed to test safety and efficacy low-density lipoprotein cholesterol (LDL-C) (a) [Lp(a)] removal by DALI high rates order reduce treatment time. Thirteen chronic patients seven centers suffering from hypercholesterolemia (LDL-C 162 ± 42 mg/dl baseline) coronary artery disease were treated on a weekly or biweekly basis apheresis. QB held constant for least two sessions, respectively, increased 60 80, 120, 160, 200, 240 ml/min. All had pre-existing av-fistulas. anticoagulation heparin bolus plus ACD-A ratio citrate: ranging 1:20 1:90. Clinically, sessions well tolerated only 26/201 (12%) treatments fraught minor adverse events. Acute LDL-C reductions (derived levels determined electrophoresis) averaged 72/66/60/53/50/48% = 60/80/120/160/200/240 Lp(a) 68/67/62/60/58/56%, whereas HDL-C losses ≤10%. Routine chemistries cell counts remained normal range. Treatment 142/83/45 min Qb 60/120/240 On average, could be safely effectively up 120 ml/min good access, significantly reduced time 142 83 (−42%). J. Clin. Apheresis 18:157–166, 2003. © 2003 Wiley-Liss, Inc.