Direct Adsorption of Low-Density Lipoprotein by DALI-LDL-Apheresis: Results of a Prospective Long-term Multicenter Follow-up Covering 12 291 Sessions

摘要: Direct adsorption of lipoproteins (DALI) is the first low density lipoprotein (LDL)-apheresis technology by which atherogenic LDL and lipoprotein(a) (Lp(a)) can be selectively removed from whole blood without plasma separation. The present follow-up was carried out to evaluate clinical efficacy, selectivity safety long-term DALI apheresis. in an open, prospective uncontrolled multicenter design. Included were 158 drug-resistant hypercholesterolemic patients 28 apheresis centers. These underwent 12 291 sessions between January 1997 March 2002. suffered severe atherosclerosis their mean LDL-C 188 mg/dL before sessions. Mean 25 +/- 16 (range 1-56) months during 78 53 out. In most treatments, 750 (63%) or 1000 (30%) adsorbers used. On average, 7423 1495 mL processed at a flow rate 84 mL/min 102 min. Acute reductions single averaged 69 12% for LDL-C, 41 18% TG, 15 10% HDL-C, 19 11% fibrinogen 62 24% Lp(a) (in with > 30 mg/dL). Adverse events recorded only 3.9% this 5-year follow-up, therapy safe, effective selective as could reduced >60% per session approximately 100 min treatment time while HDL-C decrease incidence AE low.