MODIFIED CELLS EXPRESSING A PROTEIN THAT MODULATES ACTIVITY OF bHLH PROTEINS, AND USES THEREOF
作者： Jaideep Chaudhary , Michael K. Skinner
DOI:
关键词: Interleukin 3 、 BHLH Proteins 、 Gene sequence 、 Sertoli cell 、 Carcinogenesis 、 Cell growth 、 Molecular biology 、 A protein 、 Heterologous 、 Biology
摘要: The present invention relates to modified cells carrying a heterologous gene sequence encoding protein, such as an Inhibitor of differentiation (Id) that binds basic helix-loop-helix (bHLH) protein inhibit cell growth, and/or tumorigenesis the cells. are differentiated, proliferate and do not become tumorigenic when grafted into recipient subject. Additionally, produce factor or factors enhance viability co-grafted organs, tissues Thus, useful for testing agents effects on cells, co-grafting with transplant also enhancing thawing have been cryo-preserved. In one embodiment, Sertoli
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