Ligand-Operated Membrane Channels: Calcium (Glutamate)

摘要: Mammalian central nervous system neurons are characterized by differential responses to incoming stimuli and storage of the information elicited external stimuli. Calcium (Ca 2+ ) influx through select populations neurotransmitter-activated receptors, glutamate when coupled with induction Ca release from intracellular stores, initiates key molecular interactions enzyme activities that lead long-term changes in transcription, protein synthesis, neuronal Glutamate receptor ion channels fall into three main classes based on structure pharmacological sensitivities. These ligand-activated differentially permeable their activation can either potentiation or depression synaptic activity.