The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
作者： A. Faden , P Demediuk , S. Panter , R Vink
关键词: Biochemistry 、 Antagonist 、 Dextrorphan 、 Pharmacology 、 Competitive antagonist 、 Intracellular 、 Glutamate receptor 、 Glutamic acid 、 Traumatic brain injury 、 NMDA receptor 、 Chemistry
摘要: Brain injury induced by fluid percussion in rats caused a marked elevation extracellular glutamate and aspartate adjacent to the trauma site. This increase excitatory amino acids was related severity of associated with reduction cellular bioenergetic state intracellular free magnesium. Treatment noncompetitive N-methyl-D-aspartate (NMDA) antagonist dextrophan or competitive 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid limited resultant neurological dysfunction; dextrorphan treatment also improved after increased Thus, contribute delayed tissue damage brain trauma; NMDA antagonists may be benefit treating acute head injury.
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