Why Is Taurine Cytoprotective?

摘要: The concept that taurine exhibits cytoprotective activity was introduced in 1981. Although several studies at the time had supported notion capable of modulating Ca2+movement, most those focused on transporter affected by taurine. It only after found to prevent Ca2+-induced cellular necrosis its recognized1. Since date, numerous reports have documented high levels extracellular render cells resistant an array damaging stimuli, including ischemia-reperfusion, hyperglycemia, reactive oxygen species, heat shock, toxic xenobiotics, excitotoxicity and osmotic derangements. ability counteract these stimuli has been attributed four actions taurine: (1) osmoregulation, (2) anti-oxidant/membrane stabilizing activity, (3) conjugation (4) regulation [Ca2+]i. Indeed, stress, oxidative stress Ca2+overload are major causes apoptosis. Nonetheless, cell death is a complex phenomenon, involving interactions between other factors. For example, can damage membranes leading changes [Ca21. Conversely, [Ca2+]ican cause enhanced free radical generation mitochondria. also known affects ion transporters regulate Despite interactions, it clear each factors individually. Thus, aim this review discuss importance factor