Reversible electroporation device for inducing cell apoptosis

作者: Donata Marazzi , Mattia Ronchetti , Ruggero Cadossi , Francesca De Terlizzi

DOI:

关键词: Biomedical engineeringElectroporationAbsorbed doseWeight UnitMaterials sciencePulse generatorLimit valueRange (particle radiation)ApoptosisElectrode

摘要: A reversible electroporation device in which an electric "pulse generator (2) generates a sequence of pulses delivered to electrodes (3a, 3b) coupled tissue (5) process that cell apoptosis is be performed. The configured control the amplitude and number so amount energy per weight unit (absorbed dose) applied range between first lower limit value about 3000 J/kg second upper 4500 J/kg.

参考文章(7)
Gary Onik, Boris Rubinsky, Paul Mikus, Systems for treating tissue sites using electroporation ,(2007)
Mark E. Deem, Mark Gelfand, Douglas Sutton, Hanson Gifford, Denise Zarins, Howard R. Levin, Erik Thai, Methods and apparatus for renal neuromodulation ,(2005)
R. V. Davalos, L. M. Mir, B. Rubinsky, Tissue ablation with irreversible electroporation Annals of Biomedical Engineering. ,vol. 33, pp. 223- 231 ,(2004) , 10.1007/S10439-005-8981-8
James H. Orszulak, Robert H. Wham, Steven P. Buysse, Vessel sealing system ,(2013)
Boris Rubinsky, Jon Francis Edd, Liana Horowitz, None, Electroporation to interrupt blood flow ,(2008)