Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers
作者： James E. Hagstrom , Lori Higgs , Sean D. Monahan , Darren H. Wakefield , David B. Rozema
DOI:
关键词: Materials science 、 Amine gas treating 、 Transfection 、 Conjugate 、 Organic chemistry 、 In vivo 、 Membrane 、 Biocompatible material 、 Polymer 、 Alcohol
摘要: The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo conjugates. use reversible modification provides physiologically responsive activity modulation.
lens.org 参考文章(19)
George Y. Wu, Catherine H. Wu, Carrier system and method for the introduction of genes into mammalian cells ,(1990)
Darren Wakefield, David B. Rozema, Reversible attachment of a membrane active polymer to a polynucleotide ,(2004)
Tariq M. Rana, Delivery of sirnas ,(2003)
Suzie Hwang Pun, Gregory S. Jensen, Mark E. Davis, Methods and compositions for therapeutic use of rna interference ,(2002)
Jianzhu Chen, Herman N Eisen, Qing Ge, Compositions and methods for delivery of short interfering RNA and short hairpin RNA ,(2003)
Francis C. Szoka, Jean Haensler, Self-assembling polynucleotide delivery system ,(1993)
Matthew Cotten, Ernst Wagner, David T. Curiel, Kurt Zatloukal, Max L. Birnstiel, Christian Plank, Walter G. M. Schmidt, Berndt Oberhauser, Composition for introducing nucleic acid complexes into higher eucaryotic cells ,(1992)
Chandra Vargeese, Peter Haeberli, Tongqian Chen, Weimin Wang, Conjugates and compositions for cellular delivery. ,(2002)
Vladimir G. Budker, Jon A. Wolff, Vladimir S. Trubetskoy, James E. Hagstrom, Polyampholytes for delivering polyions to a cell ,(2002)