Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
作者： Timothy B. Lowinger , Aleksandr Yurkovetskiy , Mao Yin , Cheri A. Stevenson , Charles E. Hammond
DOI:
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摘要: A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the having following formula (I) in which W1, W2, W3, W4, W5, W6, Z1, Z2,Z3, Z4, Z5, Z9, R1, R2, R3,R4,R5, n1,n2,n3, n4, n5, and n6 are defined herein. Also disclosed methods of delivering to cytoplasm selected tissue type or cell reducing expression gene subject need thereof with polymer.
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