Anti-apoptotic genes of baculoviruses.

摘要: Baculoviruses possess two different classes of genes with anti-apoptptic activity: p35 and iap. The gene product (P35) is able to block apoptosis induced by a variety stimuli in phylogenetically diverse organisms. P35 has recently been shown be capable inhibiting the ICE/ced-3 family cysteine proteases, enzymes which are implicated cell death exhibit specificity for cleavage at aspartate residues. products iap distinct class proteins containing carboxyl ring finger tandem duplications unique motif known as BIR motif. Homologues baculovirus have identified human genome. Both anti-apoptotic will continue important tools defining pathways involved apoptosis. Since our demonstration 1991 that prevents host cells from undergoing expressing p35(Clem et al., 1991), study baculovirus-induced they led discoveries far-reaching implications viral pathogenesis, disease, death. It now eukaryotic viruses encode allow them control cellular Understanding mechanism(s) these act provides fundamental insights into regulating In this review, we discuss inhibition baculoviruses, concentrating mainly on nature mechanism action genes, iap, diversity ofeukaryotes.