Production of lovastatin by a wild strain of Aspergillus terreus
作者： György Szakács , György Morovján , Robert P. Tengerdy
关键词: Lovastatin 、 Botany 、 Fermentation 、 Yield (chemistry) 、 Aspergillus terreus 、 Rapeseed 、 Lactose 、 Biology 、 Sweet sorghum 、 Dry weight 、 Food science
摘要: Of 68 Aspergillus terreus, three produced lovastatin with equivalent or better yield than strain ATCC 20542 originally described for production. Medium optimization experiments the best isolate (TUB F-514) indicated that lactose, rapeseed meal and KNO3 were carbon, organic nitrogen inorganic sources, respectively. In shake-flasks optimized medium containing 4 % (w/v) 400 μg lovastatin/ml was produced, a of 10 mg/g lactose. solid substrate fermentation on extracted sweet sorghum pulp supplemented cheese whey 1500 lovastatin/g dry weight 37.5 © Rapid Science Ltd. 1998
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