Bioprocess Engineering Aspects of the Cultivation of a Lovastatin Producer Aspergillus terreus

摘要: The aim of this work is to review bioprocess engineering aspects lovastatin (antihypercholesterolemia drug) production by Aspergillus terreus in the submerged culture bioreactors various scale presented scientific literature since nineties twentieth century. key factor influencing cultivation any filamentous species fungal morphology and that why aspect was treated as starting point for further considerations. Fungal known have an impact on following issues connected with A. reviewed article. These are broth viscosity conjunction non-Newtonian behaviour broths, multistage oxygen transfer processes: from gas phase (air) liquid (broth) diffusion agglomerates. latest achievements concerning controlling during biosynthesis use morphological techniques were also reviewed. Last but not least, some attention paid type a bioreactor, its operational mode kinetic modelling terreus.