A novel electrospun-aligned nanoyarn-reinforced nanofibrous scaffold for tendon tissue engineering.
作者： Chengwei Yang , Guoying Deng , Weiming Chen , Xiaojian Ye , Xiumei Mo
DOI: 10.1016/J.COLSURFB.2014.06.061
关键词: Materials science 、 Nanofiber 、 Tendon 、 Scaffold 、 Ultimate tensile strength 、 Biomedical engineering 、 Biocompatibility 、 Porosity 、 Fibroin 、 Electrospinning
摘要: An electrospun-aligned nanoyarn-reinforced nanofibrous scaffold (NRS) was developed for tendon tissue engineering to improve mechanical strength and cell infiltration. The novel composed of aligned nanoyarns random nanofibers fabricated via electrospinning using a two-collector system. aim the present study investigate three different types electrospun scaffolds (random scaffold, NRS) based on silk fibroin (SF) poly(l-lactide-co-caprolactone) blends. Morphological analysis demonstrated that NRS randomly distributed formed 3D microstructure with relatively large pore sizes high porosity. Biocompatibility revealed bone marrow-derived mesenchymal stem cells exhibited higher proliferation rate when cultured compared other scaffolds. testing results indicated tensile properties were reinforced in direction parallel satisfied requirements repair. In addition, infiltration significantly enhanced NRS. conclusion, its improved porosity appropriate properties, shows promise applications.
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