Effects of Polydopamine Functionalization on Boron Nitride Nanotube Dispersion and Cytocompatibility.
作者： Marc A. Fernandez-Yague , Aitor Larrañaga , Olga Gladkovskaya , Alanna Stanley , Ghazal Tadayyon
DOI: 10.1021/ACS.BIOCONJCHEM.5B00257
关键词: Aqueous solution 、 Dispersion (chemistry) 、 Pulmonary surfactant 、 Polymer 、 Boron nitride 、 Surface modification 、 Chemistry 、 Nanotechnology 、 X-ray photoelectron spectroscopy 、 Transmission electron microscopy
摘要: Boron nitride nanotubes (BNNTs) have unique physical properties, of value in biomedical applications; however, their dispersion and functionalization represent a critical challenge successful employment as biomaterials. In the present study, we report process for efficient disentanglement BNNTs via dual surfactant/polydopamine (PD) process. High-resolution transmission electron microscopy (HR-TEM) indicated that individual become coated with uniform PD nanocoating, which significantly enhanced aqueous solutions. Furthermore, cytocompatibility PD-coated was assessed vitro cultured human osteoblasts (HOBs) at concentrations 1, 10, 30 μg/mL over three time-points (24, 48, 72 h). this study it demonstrated PD-functionalized individually localized within cytoplasm by endosomal escape up to PD-BNNTs were cytocompatible HOBs cells following h exposure.
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