An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis.
作者： Robert J. DeLorenzo , David A. Sun , Robert E. Blair , Sompong Sombati
DOI: 10.1016/S0074-7742(06)81005-6
关键词: Glutamate receptor 、 Biology 、 Population 、 Premovement neuronal activity 、 Electrophysiology 、 Glutamic acid 、 Neuroscience 、 Epilepsy 、 Epileptogenesis 、 Calcium in biology
摘要: Stroke is a major risk factor for developing acquired epilepsy (AE). Although the underlying mechanisms of ischemia‐induced epileptogenesis are not well understood, glutamate has been found to be associated with both epileptogenesis and ischemia‐induced injury in several research models. This chapter discusses the development of an in vitro model of epileptogenesis induced by glutamate injury in hippocampal neurons, as found in a clinical stroke, and the implementation of this model of stroke‐induced AE to evaluate calcium's role …
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