Chronic inhibition of cortex microsomal Mg2+/Ca2+ ATPase‐mediated Ca2+ uptake in the rat pilocarpine model following epileptogenesis
作者： J. Travis Parsons , Severn B. Churn , Robert J. DeLorenzo
DOI: 10.1046/J.1471-4159.2001.00576.X
关键词:
摘要: In the rat pilocarpine model, 1 h of status epilepticus caused significant inhibition Mg2+/Ca2+ ATPase-mediated Ca2+ uptake in cortex endoplasmic reticulum (microsomes) isolated immediately after episode. The model is also an established acquired epilepsy. Several weeks initial episode, rats develop spontaneous recurrent seizures, or To determine whether persists establishment epilepsy, was studied cortical microsomes from displaying seizures for 1 year. rate and total epileptic animals remained significantly inhibited year expression epilepsy compared to age-matched controls. not due individual nor artifact increased release microsomes. addition, decreased either selective isolation damaged homogenate ATPase protein data demonstrate that microsomal may underlie some long-term plasticity changes associated with epileptogenesis.
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