Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma.

摘要: Hepatocellular carcinoma (HCC) is one of the most common human malignancies and third leading cause cancer mortality worldwide. The development progression HCC a complicated process, involving deregulation multiple genes that are essential to cell biological processes. Recently, microRNAs (miRNAs) have been suggested be closely associated with tumorigenesis. Our study showed miR-184 upregulated in lines tissues. Overexpression cells increased proliferation, tumorigenicity, cycle progression, whereas inhibition reduced progression. Additionally, we identified SOX7 as direct target miR-184. Ectopic expression led downregulation protein, resulting upregulation c-Myc, Cyclin D1, phosphorylation Rb. findings represents potential onco-miR plays an important role by suppressing expression.