Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical results
作者： Sharon Berendsen , Marike Broekman , Tatjana Seute , Tom Snijders , Corine van Es
DOI: 10.1517/13543784.2012.694425
关键词: Histone 、 Transcription factor 、 Valproic Acid 、 Brain tumor 、 DNA repair 、 Pharmacology 、 Mood stabilizer 、 Kinase 、 Glioma 、 Medicine
摘要: Introduction: Glioblastoma multiforme is the most common and aggressive primary brain tumor. Valproate has been used as an anti-epileptic drug mood stabilizer for decades. Recently, it was found to inhibit proliferation of various cancers including glioblastoma multiforme. Areas covered: We provide a comprehensive review mechanisms action valproate in gliomas, its potential side effects published clinical results obtained with this glioblastomas. inhibits subset histone deacetylases cellular kinases, affects gene transcription through hyperacetylation, DNA hypomethylation modulation several factors. As result, VPA induces differentiation glioma cells, can prevent their invasion surrounding tissues may tumor angiogenesis. also repair, thereby potentiating cytotoxic treatments such chemotherapies or radiation therapy. Based on these case reports glio...
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