An unusual composite endometrial tumor combining papillary serous carcinoma and small cell carcinoma.

摘要: This is the first report in English literature of a composite endometrial tumor composed papillary serous carcinoma and small cell carcinoma. A 79-year-old woman underwent total abdominal hysterectomy left salpingo-oophorectomy due to Grossly, uterus was enlarged with an irregular nodular serosal surface, thickened myometrium, endometrium. Microscopic examination revealed There differential immunoreactivity between two components: cells were positive for cytokeratin, CA-125, CEA, HER-2/Neu, whereas these markers negative Various neuroendocrine Fluorescence situ hybridization analysis using 4, 8, 10 centromeric probes hyperploidy (6-8 signals) cells. Most euploid, scattered trisomies tetrasomies chromosomes. The patient died progressive disease 5 months after surgery. We suggest that may have arisen from undergoing progression differentiation.