Hepatocellular enzyme patterns and hepatitis B virus exposure in multitransfused young and very young hemophilia patients.

摘要: Thirty-eight children with severe hemophilia A, 11 years of age and under, were evaluated by initial follow-up liver function tests (LFTs) in relation to onset transfusion therapy. Each child had at least two complete evaluations within one year for a period year. The mean number exposure days was 36 275 units factor VIII per day prior LFTs. At testing, 30% patients demonstrated antibody HBsAg 39--51% abnormal serum enzyme level (AST, ALT, LDH). During an average 34.8 months, developed HBsAg-positive icteric hepatitis. Of those initially serologically negative or antibody, 44% became antibody-positive. Intermittent abnormalities observed 79% the patient group, 13% 8% being persistently normal abnormal. Eleven born after January 1976, receiving only third-generation RIA-tested products HBsAg, constituted subgroup. Although first assessment evidence hepatitis B virus exposure, 55% elevated ALTs, indicating considerable frequency non-A, non-B this very young group.