Infecção pelo vírus da hepatite B em hemofílicos em Goiás: soroprevalência, fatores de risco associados e resposta vacinal
作者： Renato S. Tavares , Adriana P. Barbosa , Sheila A. Teles , Megmar A. S. Carneiro , Carmen L. R. Lopes
DOI: 10.1590/S1516-84842004000300007
关键词:
摘要: Objetivando determinar a prevalencia da infeccao pelo virus hepatite B (HBV) em hemofilicos Goias, analisar os fatores de risco associados e avaliar resposta vacinal contra B, 102 pacientes foram entrevistados amostras sanguineas coletadas para deteccao dos seguintes marcadores sorologicos: HBsAg, anti-HBs anti-HBc. Uma global 43,7% (IC 95%: 33,5-54,2) HBV foi encontrada. A analise multivariada mostrou que o numero episodios transfusionais sorologia positiva C estiveram significantemente positividade ao HBV. Foram identificados 49 (48,1%) susceptiveis esta infeccao, sendo imunizados 30 com vacina recombinante Euvax-B. Destes, 28 (93,3%) individuos apresentaram titulos maiores 10 UI/L, mostra uma boa vacina. Os achados deste estudo ressaltam importância das medidas controle prevencao nesta populacao.
sci-hub.se 参考文章(34)
DB Brettler, HJ Alter, JL Dienstag, AD Forsberg, PH Levine, Prevalence of hepatitis C virus antibody in a cohort of hemophilia patients. Blood. ,vol. 76, pp. 254- 256 ,(1990) , 10.1182/BLOOD.V76.1.254.254
M. Hofer, H. I. Joller-Jemelka, P. J. Grob, R. Lüthy, M. Opravil, , Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen only. Swiss HIV Cohort Study. European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 17, pp. 6- 13 ,(1998) , 10.1007/BF01584356
M. Dusevic, B. E. Lukie, R. T. Card, Coagulation factor therapy for hemophilia: relation to hepatitis B and to liver function Canadian Medical Association Journal. ,vol. 126, pp. 34- 36 ,(1982)
Celina Maria Turchi Martelli, Ana Lúcia Sampaio Sgambatti de Andrade, Divina das Dores Paula Cardoso, Simonne Almeida e Silva, Fabio Zicker, Considerações metodológicas na interpretação do rastreamento sorológico da hepatite B em doadores de sangue Revista De Saude Publica. ,vol. 25, pp. 11- 16 ,(1991) , 10.1590/S0034-89101991000100003
J P Allain, S H Dailey, Y Laurian, D S Vallari, A Rafowicz, S M Desai, S G Devare, Evidence for persistent hepatitis C virus (HCV) infection in hemophiliacs. Journal of Clinical Investigation. ,vol. 88, pp. 1672- 1679 ,(1991) , 10.1172/JCI115482
Anders Widell, Bengt Göuran Hansson, Erik Nordenfelt, Erik Berntorp, Torkil Moestrup, Holger Hansson, Hugo P. Johansson, Antibody to a hepatitis C virus related protein among patients at high risk for hepatitis B. Scandinavian Journal of Infectious Diseases. ,vol. 23, pp. 19- 24 ,(1991) , 10.3109/00365549109023369
Margaret W. Hilgartner, Patricia Giardina, Liver dysfunction in patients with hemophilia. Scandinavian Journal of Haematology. ,vol. 19, pp. 6- 10 ,(2009) , 10.1111/J.1600-0609.1977.TB01511.X
Wendy Chan, Martin Petric, Elaine Wang, Gideon Koren, Stanley Read, Blanchette Victor, Response to hepatitis B immunization in children with hemophilia: Relationship to infection with human immunodeficiency virus type 1 The Journal of Pediatrics. ,vol. 117, pp. 427- 430 ,(1990) , 10.1016/S0022-3476(05)81086-8
E. D. Gomperts, J. Lazerson, D. Berg, D. Lockhart, E. Sergis-Deavenport, Hepatocellular enzyme patterns and hepatitis B virus exposure in multitransfused young and very young hemophilia patients. American Journal of Hematology. ,vol. 11, pp. 55- 59 ,(1981) , 10.1002/AJH.2830110107
J. Michael Soucie, Lisa C. Richardson, Bruce Lee Evatt, Jeanne V. Linden, Bruce M. Ewenstein, Sidney F. Stein, Cindy Leissinger, Marilyn Manco-Johnson, Charles L. Sexauer, , Risk factors for infection with HBV and HCV in a largecohort of hemophiliac males. Transfusion. ,vol. 41, pp. 338- 343 ,(2001) , 10.1046/J.1537-2995.2001.41030338.X