Preparation of micron-scale monodisperse oil-in-water microspheres by microchannel emulsification
作者： Isao Kobayashi , Mitsutoshi Nakajima , Hiroshi Nabetani , Yuji Kikuchi , Atsushi Shohno
DOI: 10.1007/S11746-001-0345-5
关键词: Dispersity 、 Dispersion (chemistry) 、 Fatty acid ester 、 Phase (matter) 、 Microchannel 、 Microparticle 、 Pulmonary surfactant 、 Analytical chemistry 、 Materials science 、 Soybean oil 、 Chromatography
摘要: Micron-scale monodisperse oil-in-water (O/W) micropheres (MS) were prepared using a novel microchannel (MC) emulsification technique. The characteristics of the MS preparation and O/W-MS studied. Soybean oil medium-chain triacyglycerol (MCT) used as disprrsed phase, physiological saline was continuous phase. Silicon MC with 1 to 3μm-equivalent channel diameters employed. A module devised easily recover prepared. effects shape on behavior formation, size, distribution investigated. An terrace at outlet stably yielded micron-scale O/W-MS; had about 5 μm, their coefficients variation below 9%. Monodisperse food-grade 4 μm could be obtained by polyglycerol fatty acid ester surfactant. size recovered remained almost constant over 60 d, demonstrating long-term stability.
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