Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

摘要: Background Urologists are frequently confronted with questions of urinary bladder cancer (UBC) patients about what they can do to improve their prognosis. Unfortunately, it is largely unknown which lifestyle factors influence Objective To systematically review the available evidence on association between body mass index (BMI), diet, dietary supplements, and physical activity UBC Methods We searched PubMed Embase up May 2017. included thirty-one articles reporting observational randomized controlled trials investigating BMI, diet supplements in relation recurrence, progression, cancer-specific or all-cause mortality patients. Results In non-muscle invasive (NMIBC) patients, both overweight (3 studies, pooled hazard ratio (HR) 1.29, 95% CI 1.05-1.58, I2 = 0%) as well obesity HR 1.82, 1.12-2.95, 79%) were associated increased risk recurrence when compared normal weight. No BMI progression was found. for prognosis muscle-invasive all stages series inconsistent. Observational studies showed inconsistent results. have been published date. Conclusions Evidence an limited, some NMIBC. Well-designed, prospective needed develop evidence-based guidelines this topic.