Modulation of transcriptional activity in brain lower grade glioma by alternative splicing
作者： Jin Li , Yang Wang , Xianglian Meng , Hong Liang
DOI: 10.7717/PEERJ.4686
关键词: Alternative splicing 、 Exon 、 Cell biology 、 Gene isoform 、 Biology 、 Transcriptional regulation 、 Protein domain 、 Transcription factor 、 Gene 、 ELK1
摘要: Proteins that modify the activity of transcription factors (TFs) are often called modulators and play a vital role in gene transcriptional regulation. Alternative splicing is critical step processing, differentially spliced isoforms may have different functions. can modulate function by adding or removing certain protein domains thereby influence protein. The objective this study to investigate alternative modulating regulation brain lower grade glioma (LGG), especially factor ELK1, which closely related various disorders, including Alzheimer's disease Down syndrome. results showed changes exon inclusion ratio proteins APP STK16 associated with expression correlation between ELK1 its targets. In addition, structural features two strongly pathological impact inclusion. our analysis suggest alternatively functions modifying induce dysregulation multiple genes.
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