PHORBOL MYRISTATE ACETATE: A MITOGEN SELECTIVE FOR A T-LYMPHOCYTE SUBPOPULATION*
作者： J L Touraine , J W Hadden , F Touraine , E M Hadden , R Estensen
关键词: Biology 、 T lymphocyte 、 Phorbol Myristate Acetate 、 Internal medicine 、 Population 、 Bromodeoxyuridine 、 Potency 、 Mitogen-activated protein kinase 、 Concanavalin A 、 Endocrinology 、 Rosette (botany)
摘要: Phorbol myristate acetate (pma) is a potent mitogen for human peripheral blood lymphocytes (PBL) comparable to phytohemagglutinin (PHA) in potency. Inactivation of PHA-responsive by 5'-bromodeoxyuridine and light treatment left the PMA response intact nice versa. Experiments separating rosetting with sheep erythrocytes (SRBC) demonstrated that PMA-responsive segregate those have high affinity SRBC greater than PHA- or concanavalin A (Con A)-responsive cells. These results indicate population resides within T-lymphocyte appears be distinct from responding PHA Con A. may useful clinically assay size function "active" rosette population.
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Andrew Sivak, Brooke T. Mossman, B.L. Van Duuren, Activation of cell membrane enzymes in the stimulation of cell division Biochemical and Biophysical Research Communications. ,vol. 46, pp. 605- 609 ,(1972) , 10.1016/S0006-291X(72)80182-7
R. Süss, A. Schuster, Tumor-promoting croton oil factor tetradecanoyl-phorbol-acetate stimulates thymidine incorporation into normal and con a stimulated lymphocytes Cellular and Molecular Life Sciences. ,vol. 30, pp. 81- 81 ,(1974) , 10.1007/BF01921612
S. Segal, I. R. Cohen, M. Feldman, Thymus-Derived Lymphocytes: Humoral and Cellular Reactions Distinguished by Hydrocortisone Science. ,vol. 175, pp. 1126- 1128 ,(1972) , 10.1126/SCIENCE.175.4026.1126
MARC FELDMANN, PETER C. L. BEVERLEY, MARGARET DUNKLEY, SIRKKA KONTIAINEN, Different Ly antigen phenotypes of in vitro induced helper and suppressor cells. Nature. ,vol. 258, pp. 614- 616 ,(1975) , 10.1038/258614A0
Pekka Häyry, Peter J. Roberts, Annamari Ranki, Theodor Weber, Selective responses of mouse T lymphocytes to different T mitogens and in mixed lymphocyte culture induced cytolysis reaction Cellular Immunology. ,vol. 25, pp. 121- 128 ,(1976) , 10.1016/0008-8749(76)90102-7
J. F. Whitfield, J. P. Macmanus, D. J. Gillan, Calcium-dependent stimulation by a phorbol ester (PMA) of thymic lymphoblast DNA synthesis and proliferation Journal of Cellular Physiology. ,vol. 82, pp. 151- 156 ,(1973) , 10.1002/JCP.1040820203
J. L. Wang, D. A. McClain, G. M. Edelman, Modulation of lymphocyte mitogenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 1917- 1921 ,(1975) , 10.1073/PNAS.72.5.1917
H Cantor, E A Boyse, Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. Journal of Experimental Medicine. ,vol. 141, pp. 1376- 1389 ,(1975) , 10.1084/JEM.141.6.1376
J.L. Touraine, F. Touraine, J.W. Hadden, E.M. Hadden, R.A. Good, 5-Bromodeoxyuridine-Light Inactivation of Human Lymphocytes Stimulated by Mitogens and Allogeneic Cells: Evidence for Distinct T-Lymphocyte Subsets International Archives of Allergy and Immunology. ,vol. 52, pp. 105- 117 ,(1976) , 10.1159/000231672
Joseph Wybran, Alan S. Levin, H. Hugh Fudenberg, Allan L. Goldstein, THYMOSIN: EFFECTS ON NORMAL HUMAN BLOOD T-CELLS Annals of the New York Academy of Sciences. ,vol. 249, pp. 300- 307 ,(1975) , 10.1111/J.1749-6632.1975.TB29077.X