Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.

摘要: THYMUS-derived (T) cells have a major role in immune systems. They mediate various functions, such as T–B cooperation (‘helper cells’)1 and the mixed lymphocyte reaction2, become killer cells3, are active graft versus host responses (reviewed ref. 4) act suppressor cells5. The identification of responsible for these functions T was facilitated by use antisera against T-cell-specific alloantigen, Thy-1 (ref. 6) (formerly known θ). It has been reported that Ly allo-antigens, present exclusively on cells7, identify functionally distinct subpopulations cells8. For example, helper were lysed anti-Ly–1, but not anti-Ly–2, so their phenotype is Ly–1+2−, whereas subpopulation, being Ly–1−2+. We report here specific induced vitro different alloantigen from same spleen cell pool.