Cancer Risk in Population Examined With Diagnostic Doses of 131I

摘要: Previously, we conducted a study of 35,074 patients receiving diagnostic doses 131I for suspected thyroid disorders between 1951 and 1969. We reported that, 1958 1984, the incidence cancers in these was insignificantly greater than expected general population. This increase attributed to underlying condition that prompted examination not administration 131I. The purpose present analyze total cancer risk same cohort examined with To further evaluate disease patients, compared all average radiation dose approximately 500 mGy less 10 other organs. In 3,746 occurred following first 5 years after examination, resulting standardized rate (SIR) 1.01 (95% confidence interval = 0.98-1.04). SIRs were significantly increased endocrine tumors (1.93) lymphomas (1.24), leukemias (1.34), nervous system (1.19). leukemia similar chronic lymphocytic (CLL) (SIR 1.30) non-CLL 1.34). SIR decreased female genital organs (0.86). sites types combined highest 5-9 1.07) did differ from unity thereafter. With or equal follow-up, statistically associated Overall, data exclude increments 5% 1.05) 95% confidence. significant non-CLL, prominent radiogenic malignancy, however, warrants special attention. are continuing our determine possible factors involved leukemia.