Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997-2008) of a cohort of children and adolescents from Belarus exposed to radioiodines after the Chernobyl accident

摘要: Author(s): Zablotska, Lydia B; Nadyrov, Eldar A; Rozhko, Alexander V; Gong, Zhihong; Polyanskaya, Olga N; McConnell, Robert J; O'Kane, Patrick; Brenner, Alina Little, Mark P; Ostroumova, Evgenia; Bouville, Andre; Drozdovitch, Vladimir; Minenko, Viktor; Demidchik, Yuri; Nerovnya, Alexander; Yauseyenka, Vassilina; Savasteeva, Irina; Nikonovich, Sergey; Mabuchi, Kiyohiko; Hatch, Maureen | Abstract: BackgroundRecent studies of children and adolescents who were exposed to radioactive iodine-131 (I-131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose-related increase risk thyroid cancer, but association radiation doses with tumor histologic morphologic features is not clear.MethodsA cohort 11,664 individuals Belarus aged ≤18 years at time underwent 3 cycles screening during 1997 2008. I-131 estimated from individual activity measurements taken within 2 months dosimetric questionnaire data. Demographic, clinical, pathologic characteristics patients cancer analyzed using 1-way analysis variance, chi-square tests or Fisher exact tests, logistic regression.ResultsIn total, 158 cancers identified as result screening. The majority had T1a T1b tumors (93.7%), many positive regional lymph nodes (N1; 60.6%) few distant metastases (M1; l1%). Higher associated higher frequency solid diffuse sclerosing variants (P l .01) aggressiveness, such lymphatic vessel invasion, intrathyroidal infiltration, multifocality (all P .03). Latency was correlated dose. Fifty-two self-reported which diagnosed before younger percentage variant compared screening-detected .0001).ConclusionsI-131 significantly greater various aggressiveness.