The DBP Phenotype Gc-1f/Gc-1f Is Associated with Reduced Risk of Cancer. The Tromsø Study
作者： Rolf Jorde , Henrik Schirmer , Tom Wilsgaard , Ellisiv Bøgeberg Mathiesen , Inger Njølstad
DOI: 10.1371/JOURNAL.PONE.0126359
关键词: Type 2 diabetes 、 Vitamin D-binding protein 、 Carcinogenesis 、 Internal medicine 、 Endocrinology 、 Single-nucleotide polymorphism 、 Vitamin D and neurology 、 Medicine 、 Bioinformatics 、 Genotyping 、 Allele 、 Cancer
摘要: Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation carcinogenesis. There are three common variants of DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six phenotypes (1s/1s, 1s/1f, 1s/2, 1f/1f, 1f/2, 2/2). These can be identified by genotyping for two single nucleotide polymorphisms rs7041 rs4588 GC gene. The DBP have different coefficients metabolites, accordingly there important relations between health. Methods DNA was prepared from subjects who participated fourth survey Tromso Study 1994-1995 were registered with endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer or death well randomly selected control group. endpoint registers complete up 2010- 2013. Genotyping performed serum 25-hydroxyvitamin (25(OH)D) measured. Results Genotyping successfully 11 704 subjects. Among these, 1660 incident MI, 958 T2DM, 2410 4318 had died. Subjects phenotype 1f/1f 23 – 26 % reduced risk compared 1s/1s 2/2 (P < 0.02, Cox regression gender covariate). Differences 25(OH)D levels could not explain apparent protective effect variant 1f. In 25(OH)D, significant associations body height, hip circumference calcium. Conclusion There biological differences phenotypes. If relation 1f is confirmed other studies, determination clinical importance.
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