Vitamin D Status and Cancer Incidence and Mortality

摘要: The role of excessive sun exposure in increasing risk skin cancers is well established. Less known, less established and more controversial the potential reducing several types internal cancers. hypothesis that sunlight may be beneficial against cancer extends back almost seven decades. Initially, Peller Stephenson observed higher rates cancer, but lower other malignancies United States Navy personnel 1930s.1 Based on this observation, hypothesized acquiring conferred immunity Several years later, Apperly an association between latitude mortality rate, which led him to state “The presence really occasional accompaniment a relative some way related solar radiation”.2 However, no plausible mechanism was proffered these observations were essentially ignored for about four In 1980, Garland colleagues benefit attributed vitamin D.3 centered colon cancer,3 later it extended breast cancer,4 ovarian cancer,5 prostate cancer,6,7 multiple types.8