Systems genetics analysis of cancer susceptibility: from mouse models to humans
作者： David Quigley , Allan Balmain
DOI: 10.1038/NRG2617
关键词:
摘要: Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects common alleles. This may due to unknown gene-gene or gene-environment interactions and complex roles many genes at different stages cancer. Studies using mouse models suggest methods integrate genetic analysis genomic networks with knowledge biology can help extend our understanding susceptibility.
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