Effect of intraoperative low-dose dopamine on renal function in liver transplant recipients.

摘要: Patients undergoing orthotopic liver transplantation frequently receive dopamine infusions to preserve renal function. To test the benefit of such on function, 48 nonanuric patients presenting for OLT were entered into a randomized double-blind protocol. After exclusion 1 patient intraoperative nephrectomy, 22 received at rate 3 micrograms.kg-1.min-1 during surgery and first postoperative h, control group 25 saline. Venovenous bypass was used in 45 47 patients. During hepatic vascular anastomoses, donor flushed with cold In 7 patients, flush contained mannitol (50 g) as part surgical protocol investigate its role potential free radical scavenger. Initially, it appeared that there an increase urine output neohepatic phase those receiving versus controls (4.20 +/- 3.3 vs 2.10 1.3 ml.kg-1.h-1, respectively). Upon further statistical analysis, this associated inclusion 5 group. excluding all containing mannitol, no significant difference between (2.94 0.45 0.28 The glomerular filtration rates month after similar decreased approximately 40% each Although beneficial effect situations cannot be ruled out authors conclude routine perioperative use is little value transplantation.