Synthesis, computational studies and preliminary pharmacological evaluation of 2-[4-(aryl substituted) piperazin-1-yl]-N-benzylacetamides as potential antipsychotics
作者： Sushil Kumar , A.K. Wahi , Ranjit Singh
DOI: 10.1016/J.ARABJC.2012.03.016
关键词: Apomorphine 、 Stereochemistry 、 Clozapine 、 Lead compound 、 Atypical antipsychotic 、 Risperidone 、 Aryl 、 Catalepsy 、 Chemistry 、 Ketanserin
摘要: Abstract A series of 2-[4-(aryl substituted) piperazin-1-yl]- N -benzylacetamides were synthesized and the target compounds ( 3a–j ) evaluated for atypical antipsychotic activity by studying apomorphine induced climbing behavior, 5-HTP head twitches behavior catalepsy in mice. The physicochemical similarity with respect to standard drugs clozapine, ketanserin risperidone was assessed calculating from a set properties using software programs. test demonstrated good values drugs. Among them, compound 3b has emerged as an important lead showing potential antipsychotic-like profile.
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